Dysregulation of mmp2-dependent tgf-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis

HIGHLIGHTS

• What: The authors investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies. The authors show that T2D plaques have smaller fibrous caps due to hyperglycemia-dependent reduction of MMP2 activity, affecting synthetic vascular smooth muscle migration and TGF-β2 cleavage, which in turn limits VSMC differentiation and collagen formation. This study identified that T2D plaques have smaller fibrous caps, lower total collagen levels and smaller total plaque areas of collagen. By spatial deep sequencing, the authors . . .
  

   

  

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