Dystrophin’s central domain forms a complex filament that becomes disorganized by in-frame deletions

HIGHLIGHTS

• who: Olivier Delalande from the (UNIVERSITY) have published the research work: Dystrophin's central domain forms a complex filament that becomes disorganized by in-frame deletions, in the Journal: (JOURNAL) of February/22,/2018
• how: The authors applied the interactive flexible fitting procedure the authors developed previously (Ref 27 and Movie S1) to explore the possible deformations of the spectrin-based homology models.

SUMMARY

Mutations of the dystrophin DMD gene are the cause of two progressive muscle diseases of variable severity, Duchenne and Becker muscular dystrophy (DMD4 and BMD, respectively). Dystrophin . . .

 



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