Dystrophy-associated caveolin-3 mutations reveal that caveolae couple il6/stat3 signaling with mechanosensing in human muscle cells

HIGHLIGHTS

• who: Melissa Dewulf from the Institut Research University have published the paper: Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors explored the mechanical role of caveolae in human muscle cells and their possible deregulation in caveolinopathies, a family of muscle genetic disorders involving mutations in the CAV3 gene. The authors focused the investigations on the human CAV3 P28L mutation responsible for hyperCKemia24, and CAV3 R26Q, which is responsible for ripple muscle disease, hyperCKemia, and limb . . .
  

   

  

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