E-cadherin maintains the undifferentiated state of mouse spermatogonial progenitor cells via β-catenin

HIGHLIGHTS

• who: Weixiang Song from the Technology, Agricultural University, China have published the article: E-cadherin maintains the undifferentiated state of mouse spermatogonial progenitor cells via u03b2-catenin, in the Journal: (JOURNAL)
• what: The authors demonstrated that conditional disfunction of E-cadherin in germ cells promoted differentiation, but deletion of E-cadherin in SPCs through CRISPR/Cas9 not only gave rise to differentiation, but also reduced anti-apoptosis capacity. Collectively, the authors focused on the regulatory mechanism of E-cadherin in SPCs, demonstrating a potential regulatory pattern of SPCs maintenance mediated by E-cadherin and CDH22 . . .
  

   

  

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