HIGHLIGHTS
- who: M. Charlotte Hemmer from the Department University Medical have published the article: E47 modulates hepatic glucocorticoid action, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show that crosstalk between E47 and GR plays a role in hepatic lipid and glucose metabolism. Using ChIP to map GR binding in mouse livers together with hepatocyte-specific E47 mutant mice, the authors demonstrate that GR and E47 synergize to mediate the metabolic actions of GCs at the genomic level.
SUMMARY
When GCs bind to the Glucocorticoid Receptor (GR), it translocates from . . .
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