HIGHLIGHTS
SUMMARY
The authors previously reported that visceral hypersensitivity lasted considerably longer in CPH (> 13 weeks) compared to stress-induced visceral hypersensitivity (SIH) rats (3-4 weeks); however, during the first few weeks following stress the magnitude of pain hypersensitivity and its associated peripheral mechanisms, including corticotrophin-releasing factor signaling and mast cell activation were similar in SIH and CPH rats. Surprisingly, while peripheral sensitization persisted for at least 7 weeks in both SIH and CPH rats, different phenotypes of dorsal horn neurons were sensitized at 7 weeks in CPH rats compared to those observed at . . .
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