Early detection of male-predominant phenotypes in the pattern of ultrasonic vocalizations emitted by autism spectrum disorder model (crmp4-knockout) mice

HIGHLIGHTS

SUMMARY

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Although recent studies focusing on sex differences in animal models of ASD have gradually increased, suitable models to analyze sex differences in ASD pathogenesis remain insufficient. The authors used Crmp4-KO mice exhibiting some ASD-like phenotypes in a male-predominant manner and determined whether analyzing USVs can detect genotypeand sex-based differences in neonatal ASD model mice. The total number of USVs, as well as the number of calls in each category, was used to assess the communication ability of ASD model pups. Tbx1 . . .

 



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