Early disruption of extracellular pleiotrophin distribution alters cerebellar neuronal circuit development and function

HIGHLIGHTS

• who: M. M. Hamza from the University of Rouen, Mont-Saint-Aignan , France have published the research: Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function, in the Journal: (JOURNAL)
• what: The authors investigate the effects of PTN on the distribution of the ionotropic glutamate receptor subunit GluRu03b42 and the two vesicular glutamate transporters (VGluT1 and VGluT2) on the Purkinje cells. To conclude, the study demonstrated that an early disruption of the ECM composition induced by a subarachnoidal administration of PTN leads to significant decrease of the dendritic component of Purkinje . . .
  

   

  

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