HIGHLIGHTS
SUMMARY
This early life biological embedding predicts that exposure to nonpathogenic microorganisms or their metabolites can reprogram the threshold and function of innate immune_responses to confer increased and persistent immunocompetence, echoing the emerging concept of "trained immunity." Despite the lack of memory lymphocytes, C. gigas possesses potent immune cells called hemocytes which are able to induce efficient innate immune_responses based on highly conserved immune features among which the NF-κB and IFN-like pathways. Recent studies have also shown that oyster immune system can be stimulated to improve their immune_response toward bacterial or viral pathogens . . .
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