Early macrophage response to obesity encompasses interferon regulatory factor 5 regulated mitochondrial architecture remodelling

HIGHLIGHTS

• who: L. Orliaguet from the regulation of Ghitm in vATMs, but not in scATMs (Fig7g, S C). In functional analyses, we found negative association trends between , expression and Mt Mass, mΔΨ and mΔΨ-to-mass ratio in vATMs, and mΔΨ-to-mass ratio in monocytes (Fig., h, S D). These results demonstrate that the IRF5-GHITM axis is conserved in humans and may be associated with mitochondrial adaptation of ATMs and monocytes in obesity and T D. To evaluate the potential for transcriptional regulation, we stained monocytes from patients with T D for , and for oxidative phosphorylation . . .
  

   

  

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