Early postnatal serotonin modulation prevents adult-stage deficits in arid1b-deficient mice through synaptic transcriptional reprogramming

HIGHLIGHTS

• who: Hyosang Kim from the Centrosome have published the Article: Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming, in the Journal: (JOURNAL) of 10/Dec/2021
• what: The authors report here that Arid1b-happloinsufficient (Arid1b+/-) mice display autistic-like behaviors at juvenile and adult stages accompanied by persistent decreases in excitatory synaptic density and transmission. The authors demonstrated that early, chronic fluoxetine treatment of Arid1b+/- mice prevents transcriptomic, synaptic, and behavioral deficits in adults, suggesting that early postnatal treatment is critical for long-lasting prevention of ARID1B . . .
  

   

  

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