HIGHLIGHTS
- What: The authors show that plays a major role at initial stages of disaggregation determining its final efficacy. The authors demonstrate for the first time that disrupts the interaction. The authors propose that the limited destabilisation of the chaperone complex disaggregation but also leads to the inhibition above the substoichiometric optimum. This suggests that the tuned proportion the co-chaperones of is critical to reach its disaggregating potential. eLife assessment This study provides an important insight into the mechanisms of cooperation and its cochaperones during disaggregation.
- Who: Biochemistry and collaborators from the Intercollegiate Faculty of . . .
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