Ectopic expression of aid in a non-b cell line triggers a:t and g:c point mutations in non-replicating episomal vectors

HIGHLIGHTS

• who: Vectors and colleagues from the Institut Pasteur, Paris, France have published the paper: Ectopic Expression of AID in a Non-B Cell Line Triggers A:T and G:C Point Mutations in Non-Replicating Episomal Vectors, in the Journal: (JOURNAL)
• what: The authors show that when using non-replicative episomal containing a GFP gene inactivated by the introduction of stop codons at various positions a high level of EGFP positive cells was obtained after transient expression in Jurkat cells constitutively expressing AID. The authors show that mutations at G:C and A:T pairs . . .
  

   

  

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