HIGHLIGHTS
- who: Albert Dahan from the Medical College of Wisconsin, United StatesDepartment of Anesthesiology, Leiden University Medical Center, Leiden, Netherlands, PainLess have published the research work: Editorial: Ketamine for treatment of acute and chronic pain: The relationship of mechanism and exposure to therapeutic outcome, in the Journal: (JOURNAL)
- what: The model describes the pharmacokinetics of the parent drug and its two sequential metabolites (norketamine and hydroxynorketamine), and describes the direct uptake of S-ketamine through the oral mucosa as well as the uptake in the gut following ingestion of the SK-OTF.
- how: The . . .
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