HIGHLIGHTS
- who: December et al. from the The Ohio State University, United States have published the paper: Editorial: Untangling energy metabolism in skeletal muscle: From physiology to pharmacology, in the Journal: (JOURNAL)
- how: As discussed by Pavlovic et_al in the final paper of this Research Topic inhibition of the mitochondrial complex I leading to energy stress and activation of AMPK the traditional explanation of metformin action had previously been confirmed in cell-based models using high micromolar or millimolar concentrations of metformin but not if metformin was used in therapeutic concentrations which are typically well below . . .
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