Effect of chromatin modifiers on the plasticity and immunogenicity of small-cell lung cancer

HIGHLIGHTS

  • who: Nicole A. Kirk from the (UNIVERSITY) have published the Article: Effect of chromatin modifiers on the plasticity and immunogenicity of small-cell lung cancer, in the Journal: (JOURNAL) of 12/Dec/2022
  • what: The study showed the importance of using genetic targeting strategies, such as CRISPR technology, as a means to assess the impact of directly inhibiting a target gene versus the off-target effects of a nonspecific inhibitor. This study provides a clear example of the efficacy of targeting chromatin modifiers to treat SCLC by enhancing the response to ICB. Based on the . . .

     

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