Effect of dexmedetomidine on ncrna and mrna profiles of cerebral ischemia-reperfusion injury in transient middle cerebral artery occlusion rats model

HIGHLIGHTS

• What: The authors aimed to investigate the impact of DEX on cerebral I/R injury using a transient middle cerebral artery occlusion (tMCAO) rats` model. This study provides novel insights into the pathogenesis of cerebral I/R injury and identifies potential therapeutic targets for the intervention. treatment for acute ischemic stroke is rapid revascularization, including intravenous thrombolysis with tissue plasminogen activator (tPA) and mechanical thrombectomy, aimed at restoring blood flow to the affected brain tissue (Herpich and Rincon, 2020). To summarize, this study demonstrated that DEX significantly reduces I/R injury in a rat model by improving . . .
  

   

  

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