Effect of double mutation (l452r and e484q) on the binding affinity of monoclonal antibodies (mabs) against the rbd—a target for vaccine development

HIGHLIGHTS

• who: Deepali Gupta et al. from the Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India have published the research: Effect of Double Mutation (L452R and E484Q) on the Binding Affinity of Monoclonal Antibodies (mAbs) against the RBDu2014A Target for Vaccine Development, in the Journal: Vaccines 2023, 11, x FOR PEER REVIEW of /2023/
• what: In the present study, the molecular mechanisms behind the impact of these mutations on the binding affinity of the RBD with each member of mAbs were investigated through MD simulations combined with the free-energy calculations method . . .
  

   

  

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