HIGHLIGHTS
SUMMARY
The administration of Iopamidol, a pH-responsive contrast agent, allows accurate quantitative assessments of extracellular tumor pH in_vivo. The aim was to investigate the efficacy of several PPIs on a castration-resistant human prostate cancer cell line by combining in_vitro and in_vivo studies addressing tumor acidosis. Tumor growth and MRI-CEST extracellular tumor pH measurements were performed in_vivo after acute or chronic Esomeprazole administration in both subcutaneous and orthotopic murine models for monitoring the treatment outcome. ANOVA analysis was applied with the post-hoc Bonferroni correction for in_vitro studies, whereas an unpaired Student`s . . .
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