HIGHLIGHTS
SUMMARY
When there is excessive adipose_tissue mass, the unbalanced expression of pro- and anti-inflammatory adipokines may result in a metabolic dysfunction. On the one hand, the adipose_tissue of obese individuals is infiltrated by a large number of macrophages. The literature search was performed according to the PICOS strategy, as follows: (P) Population: overweight or obese individuals; (I) Intervention: exercise; (C) Comparator: exercise intervention or no-exercise control; (O) Outcomes: body composition and inflammatory cytokine levels; and_(S) Study type: RCTs. BMI is a powerful predictor of overall mortality, but it has limitations in reflecting . . .
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