Effect of extracellular signal-regulated protein kinase 5 inhibition in clear cell renal cell carcinoma

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  • who: Hidenori Kanno et al. from the Department of Urology, Yamagata University Faculty of Medicine, Iida-Nishi, Yamagata, Japan have published the Article: Effect of Extracellular Signal-Regulated Protein Kinase 5 Inhibition in Clear Cell Renal Cell Carcinoma, in the Journal: (JOURNAL) of 28/06/2018
  • what: The authors demonstrated that ccRCC patients with strong ERK5 expression in their surgical specimens had poor survival; the specimens with decreased miR-143 had higher rates of strong ERK5 expression; ERK5 inhibition suppresses ccRCC-cell and endothelial-cell proliferation and survival in_vitro and in_vivo. The work shows that . . .

     

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