Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

HIGHLIGHTS

• who: Grégoire Chevalier from the CNRS Pasteur, Paris, France have published the paper: Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors have explored the mechanisms by which gut microbiota dysbiosis contributes to brain dysfunctions and behavioral abnormalities associated with depressive-like states. The authors show that the intestinal microbiota is sufficient to initiate a pathological feedforward loop for depressive disorders by impairing the eCB system in the hippocampus, a brain region strongly involved in the development . . .
  

   

  

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