Effect of immunophilin inhibitors on cochlear fibroblasts and spiral ganglion cells

HIGHLIGHTS

SUMMARY

[Fauré et_al, 2006], inflammatory cells, and upon cell death. Extracellular CypA shows proinflammatory cytokine-like behavior, is a potent chemoattractant for leukocytes, and elicits inflammatory responses. Cyps are also cytosolic receptors for the immunosuppressive drug cyclosporine A (CsA). Cyclophilins mediate the action of CsA by forming drug-dependent complexes. The exclusive binding of CsA to the active_site of CypA is the reason for many physiological effects such as mediation of immunosuppression, inhibition of the protein phosphatase activity of calcineurin, and thereby prevention of the cytokine gene transcription regulation. Heidelberg, Germany) (ICC: 1/50) were . . .

 



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