Effect of novel n -arylurea- substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in alzheimer’s dementia models

HIGHLIGHTS

• who: margo from the Department of Studies in, University of Mysore, Manasagangotri, Mysore-570006, India have published the Article: Effect of novel N -arylurea- substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimeru2019s dementia models, in the Journal: (JOURNAL)
• what: In light of these findings, in_vitro competitive M1 receptor displacement assay using male wistar rat-brain synaptosomal membrane and in_vivo pharmacological experiments for the synthesized compounds 9(a-j) testify to the reversal of scopolamine- induced memory loss and learning impairment in male wistar rats to ascertain their applicability in dementia.
 



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