Effect of pharmacokinetics and pharmacogenomics in adults with allogeneic hematopoietic cell transplantation conditioned with busulfan

HIGHLIGHTS

• who: Claire Seydoux from the some functional polymorphisms of GSTs, specifically the Glutathione-S-Transferase Alpha, (GSTA1) promoter region, may influence enzyme activity and therefore PK and toxicity [14-16]The two main promoter variants of , consist of GSTA1*A, with individuals showing lower Bu exposure, and GSTA1*B showing higher Bu exposure, but most studies have been done in children [15, ]. Pharmacogenomics (PG) data may add information to better understand the Bu exposure and thus efficacy or toxicity of Bu individually when associated with PK. The current study aims to investigate the correlation between the two . . .
  

   

  

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