HIGHLIGHTS
SUMMARY
The constituent amino_acids of primitive proteins might be different from those of today`s proteins. Proteins in living organisms are composed of about 20 types of amino_acids (Magic 20), but many hypotheses proposed that not all of the Magic 20 existed at the beginning of life. In these 2 of 10 hypotheses, primitive proteins comprised only a limited variety of amino_acids. There are two methods for estimating the components of a primitive protein: one is to examine 3D structures of peptides constructed by a limited type of amino_acids, and the other is to replace . . .

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