Effective radiosensitization of bladder cancer cells by pharmacological inhibition of dna-pk and atr

HIGHLIGHTS

• who: Ahmed Ali Chughtai and colleagues from the Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, Germany have published the paper: Effective Radiosensitization of Bladder Cancer Cells by Pharmacological Inhibition of DNA-PK and ATR, in the Journal: Biomedicines 2022, 10, 1277. of /2022/
• what: The authors provide functional evidence that DNAPK and inhibitors specifically target corresponding DDR pathways retarding the repair process at nano-molar concentrations. AZD7648 and Ceralasertib at Nano-Molar Concentrations Drastically Reduce Clonogenic Survival after Radiation Exposure Subsequently, the authors aimed to show whether DNA-PK and ATR . . .
  

   

  

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