HIGHLIGHTS
- who: AAV-mediated delivery and collaborators from the National Institutes of Health (NIH), United States Chengdu University of Traditional have published the Article: Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs, in the Journal: (JOURNAL)
- what: The authors show that P2X7 expressed on the cell surface of microglia can be effectively targeted by intracerebroventricular injection of P2X7 antagonistic nanobodies, as well as by the AAV-mediated endogenous production of such nanobodies after intracerebral or intramuscular injection of nanobody-encoding AAV1. The study evaluated the capacity of endogenously produced nanobodies . . .
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