Effects and mechanisms of sglt2 inhibitors on the nlrp3 inflammasome, with a focus on atherosclerosis

HIGHLIGHTS

• who: Liu Yang and colleagues from the United States Huazhong University of Science and have published the paper: Effects and mechanisms of SGLT2 inhibitors on the NLRP3 inflammasome, with a focus on atherosclerosis, in the Journal: (JOURNAL)

SUMMARY

Pathological changes in atherosclerosis include Frontiers in Endocrinology frontiersin.org 10.3389/fendo.2022.992937 factors induce NLRP3 and pro-IL-1b expression through stimulation of nuclear factor-kb (NF-kb). The accumulation of these structural domains eventually leads to the release of active caspase-1, converting inactive procaspase-1 to active caspase-1 through . . .

 



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