HIGHLIGHTS
- who: October and collaborators from the Yale University, United States have published the Article: Effects of cannabinoids on ligand-gated ion channels, in the Journal: (JOURNAL)
SUMMARY
Following structural characterization of series of phytocannabinoids in 1960s, CB1 and CB2 cannabinoid (CB) receptors, and endocannabinoids anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol (2-AG) were identified and shown to activate CB1 and CB2 with high affinity and efficacy (Devane et_al, 1992; Mechoulam et_al, 1995; Cristino et_al, 2020). While anandamide and other N-acylethanolamines are hydrolyzed by fatty_acid amide hydrolase (FAAH), the hydrolysis of 2 . . .
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