Effects of cyp3a4/5 and abc transporter polymorphisms on osimertinib plasma concentrations in japanese patients with non-small cell lung cancer

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  • who: Read Full License et al. from the Department of Pharmacy, University Hospital, Department of Pharmacokinetics, University Graduate School of Medicine, Japan have published the Article: Effects of CYP3A4/5 and ABC transporter polymorphisms on osimertinib plasma concentrations in Japanese patients with non-small cell lung cancer, in the Journal: (JOURNAL)
  • what: The authors investigated the effects of polymorphisms in CYP3A4 (20230G > A), CYP3A5 (6986A > G), ABCB1 (1236C > T), ABCB1 (2677G > T/A), ABCB1 (3435C > T), ABCG2 (421C > A), and ABCC2 (-24C > T) on the plasma concentration of osimertinib in 23 patients with NSCLC.
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