HIGHLIGHTS
SUMMARY
Fungi are remarkable microbial cell factories for secondary metabolite production, such as their strong and abundant secondary metabolite production capacity and chemical diversity. Environmental factors affect secondary_metabolism. Many studies have been performed to improve secondary_metabolism biosynthesis by changing the culture conditions. Single chemical/biological or biochemical signals, such as salicylic acid (SA) and ethylene, can also regulate secondary_metabolism. Nutritional conditions, including carbon sources (e_g, microcrystalline cellulose, D-galactose), nitrogen sources (e_g, ammonium sulfate, glycine, glutamine, and asparagine), and the ratio of carbon and nitrogen can also regulate secondary_metabolism. P. ostreatus has high nutritional value . . .
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