HIGHLIGHTS
- who: β-HSD and colleagues from the Southern University of Science and Technology, China have published the research: Effects of knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells, in the Journal: (JOURNAL)
- what: The authors aimed 1) to use the CRISPR-Cas9 technology and targeted chromosomal integration in SCP-1 cells to generate a HSD11B1 loss-of-function and gainof-function model and 2) to use these models for analyzing the role of local cortisol levels on adipogenic and osteogenic differentiation of MSCs. With these models the authors aim to improve . . .
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