HIGHLIGHTS
- who: Bailey D. Lyttle from the Medical School, United States University of Miami, United States have published the article: Effects of microRNAs on angiogenesis in diabetic wounds, in the Journal: (JOURNAL)
SUMMARY
Endothelial cells are lined with receptor tyrosine kinases including VEGF receptors (VEGFR) and FGF receptors (FGFR), which upon phosphorylation activate several downstream pathways including the extracellular signal-regulated kinases-mitogen activated protein_kinases (ERKMAPK) and phosphatidylinositol 3-kinase (PI3K) pathways to induce endothelial cell proliferation. The hypoxic environment created following injury induces pericytes to secrete metalloproteinases (MMPs), which release endothelial cells from . . .
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