Effects of pharmacological and environmental manipulations on choice between fentanyl and shock avoidance/escape in male and female rats under mutually exclusive and non-exclusive choice conditions

HIGHLIGHTS

  • What: This study aim was to improve the fundamental knowledge in the behavioral processes involved in drug-taking despite adverse consequences using both a mutually exclusive and non-exclusive fentanyl-vs-shock avoidance/escape choice procedure in female and male rats. Lastly, this study was conducted in a simplified environment with only the negative reinforcer (shock avoidance/ escape) and IV fentanyl concurrently available.
  • Who: Madison M. Marcus from the , AMAnimal maintenance and research were conducted in accordance with the , Guidelines of the National Institutes of Health Committee on Laboratory Animal Resources. Both enrichment and research . . .

     

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