Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity*

HIGHLIGHTS

  • who: Nicholas R. Brown from the (UNIVERSITY) have published the paper: Effects of Phosphorylation of Threonine 160 on Cyclin-dependent Kinase 2 Structure and Activity*, in the Journal: (JOURNAL) of September/30,/1998
  • what: The authors propose that this disorder can explain the differences observed in ATP and substrate binding between phosphorylated and nonphosphorylated CDK2 and the low level of phosphorylated CDK2 histone H1 kinase activity.
  • how: Similar results were obtained using His-tagged CAK1 expressed in S. cerevisiae as a source of fluorescence at 450 nm. Statistics relating to the quality of . . .

     

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