Efficacy of scf drug conjugate targeting c-kit in gastrointestinal stromal tumor

HIGHLIGHTS

• who: Dengyang Zhang from the , (TIB-202) cell line was obtained from ATCC (Manassas, USA) and cultured in RPMI , medium plus, % fetal bovine serum (FBS)GIST cell lines (GIST , with KIT, _Y578del, GIST , with KIT M L/ K E, and GIST , with KIT, _L576del/V A) were cultured in IMDM medium plus, % FBS. Mutations of KIT in these three cell lines were verified by Sanger sequencing. Primary KIT-positive GIST cells were from dissected tumor samples of GIST patients by gentle MACS Dissociator (Miltenyi Biotec, Bergisch Gladbach, Germany). Patients were provided with written informed consent using a . . .
  

   

  

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