Efficient base-catalyzed kemp elimination in an engineered ancestral enzyme

HIGHLIGHTS

• who: Luis I. Gutierrez-Rus and colleagues from the Departamento de Quimica Fisica, Facultad de Ciencias, Unidad de Excelencia de Quimica Aplicada a (UEQ), Universidad de Granada, Granada, Spain have published the Article: Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme, in the Journal: (JOURNAL) of 28/07/2022
• what: Specifically, the authors aimed at generating efficient Kemp eliminases with minimal design and screening efforts. The authors report the third step along these lines. This work demonstrated that a short polypeptide segment inserted near the new active_site has the capability of generating such . . .
  

   

  

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