Egoc inhibits toroid polymerization by structurally activating torc1

HIGHLIGHTS

• who: Manou00ebl Prouteau from the (UNIVERSITY) have published the paper: EGOC inhibits TOROID polymerization by structurally activating TORC1, in the Journal: (JOURNAL) of 21/Nov/2022
• what: The authors show that acute depletion and repletion of EGO complex (EGOC) activity is sufficient to control TOROID distribution, independently of other nutrient-signaling pathways. Based on these collective observations, the authors propose that, analogous to the binding observed in mammalian cells, active EGOC binds to helices u03b121, u03b124, u03b126 and u03b129 of Kog1.
• how: The authors compared the structure of yeast TORC1 present in TOROIDs . . .
  

   

  

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