Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing mapk hyperactivation

HIGHLIGHTS

• who: Guan-Nan Li from the (UNIVERSITY) have published the research: Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation, in the Journal: (JOURNAL) of 28/01/2022
• what: Consistent with this concept, in the present study, the authors demonstrated that elaiophylin directly acted on SHP2 and hyperactivated MAPK signaling, thus triggering paraptosis.
• how: To further verify that SHP2/SOS1/MAPK pathway activation was required for elaiophylin-induced paraptosis the authors used + 5 (u03bcM) 0 Elaiophylin CHX 0 + 10 (u03bcM) SHP099 (SHP2 inhibitor) and BAY293 (SOS1/RAS . . .
  

   

  

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