Electroacupuncture and human ipsc-derived small extracellular vesicles regulate the gut microbiota in ischemic stroke via the brain-gut axis

HIGHLIGHTS

SUMMARY

The mice were randomly divided into five groups, including the sham operation group (Sham), model group (MCAO), electroacupuncture group (EA), iPSC-EVs group (EV), and EA combined with iPSC-EVs group (EA+EV). After cerebral ischemia, its abundance increased significantly in the MCAO group, and EA, iPSC-EVs, and EA combined with iPSC-EVs treatments reduced it.The abundance of Firmicutes and Verrucomicrobia, which are beneficial bacteria, can be increased by EA. The research showed that EA, iPSC-EVs, and EA combined with iPSC-EVs treatments significantly decreased IL-17 levels and increased IL . . .

 



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