HIGHLIGHTS
- who: Sandip Patel and colleagues from the Department of Cell and Developmental Biology, University College London, London WC E BT, UK have published the paper: Electrophysiology of Endolysosomal Two-Pore Channels:A Current Account, in the Journal: Cells 2022, 2368 of /2022/
- what: This study demonstrated that TPC2 was an NAADP-gated 8 of 16 Ca2+ -permeable channel.
- future: More work is needed for TPC1 and establishing how ligand activation by NAADP and PI(35)P2 is integrated with voltage activation.
SUMMARY
Two-pore channels (TPCs) are ancient members . . .
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