Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway

HIGHLIGHTS

  • who: Celien Tigchelaar from the Department of Anaesthesiology, University Medical Center, University of, the Netherlands have published the research work: Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway, in the Journal: (JOURNAL)
  • what: The aim of this study was to determine polyol concentrations in patients without major neurological disease with normal or elevated glucose concentrations. This proof-of-concept study is relevant because the authors demonstrate an activation of the polyol pathway across a broad spectrum of plasma and CSF glucose levels in patients both with . . .

     

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