Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle

HIGHLIGHTS

• who: Justin D. Crane and colleagues from the Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada have published the article: Elevated Mitochondrial Oxidative Stress Impairs Metabolic Adaptations to Exercise in Skeletal Muscle, in the Journal: PLOS ONE | www.plosone.org of July/15,/2013
• what: The authors demonstrate that the chronic elevation in mitochondrial oxidative stress present in Sod2+/- mice impairs the functional and biochemical mitochondrial adaptations to exercise. While the causative events of these diseases remain unclear, the authors propose that excess superoxide can disrupt mitochondrial . . .
  

   

  

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