Elevated monocyte-specific type i interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application deteriorates myocardial healing in rats

HIGHLIGHTS

• who: Ellis N. ter Horst from the Animals and experimental MI procedure Male Wistar rats (n=48, age, weeks, Harlan Laboratories, Horst, the Netherlands) weighing between , and , g were usedThe study was approved by the VU University Amsterdam animal ethics and welfare committee. The VU University Amsterdam is licensed according to the, EU guidelines. The rats involved in the current study were accommodated and cared for according to the guidelines described in appendix A of EST No., . Induction of MI and the use of medetomidine-sufentanil as anaesthesia are performed as described previously [29]. Briefly, the left . . .
  

   

  

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