Elevation of anticancer drug toxicity by caffeine in spheroid model of human lung adenocarcinoma a549 cells mediated by reduction in claudin-2 and nrf2 expression

HIGHLIGHTS

• who: Hiroaki Eguchi and colleagues from the Laboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu, Japan have published the paper: Elevation of Anticancer Drug Toxicity by Caffeine in Spheroid Model of Human Lung Adenocarcinoma A549 Cells Mediated by Reduction in Claudin-2 and Nrf2 Expression, in the Journal: (JOURNAL)
• what: We found that coffee ingredients, namely caffeine and theobromine, can decrease the protein level of CLDN2 in human lung adenocarcinoma A549 cells.

SUMMARY

Cancer cells are born through the gradual acquisition of genetic alterations in an organism from . . .

 



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