Elimination of negative feedback in tlr signalling allows rapid and hypersensitive detection of microbial contaminants

HIGHLIGHTS

• who: Clovis H. T. Seumen from the Universität GermanyUniversity of have published the article: Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants, in the Journal: Scientific Reports Scientific Reports of 24/Nov/2021
• what: The authors report that deletion of SOCS1 sensitizes cells to microbial PAMPs and thereby strongly elevates and accelerates signaling output of an established NF-κB reporter system.
• how: These results indicated that the generated 8xκB-TApmCFP THP-1 cells can serve as a robust NF-κB reporter system but also . . .
  

   

  

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