HIGHLIGHTS
- who: Mark A. Tye from the (UNIVERSITY) have published the research work: Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance, in the Journal: (JOURNAL) of 11/Dec/2021
- what: Supported by this assay platform and co-crystal_structures of representative inhibitor-target complexes, the authors develop a set of high-affinity prolyl-tRNA synthetase inhibitors, including previously elusive aminoacyl-tRNA synthetase triple-site ligands that simultaneously engage all three substrate-binding pockets.
- how: In complementary efforts investigating the mode of action of halofuginone in humans where halofuginone has been . . .
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