HIGHLIGHTS
SUMMARY
In recent years, a promising strategy, namely, the regulation of cellular senescence, has emerged; cellular senescence permanently inhibits the proliferative capacity of cells, inducing irreversible cell cycle arrest. Senescent cells are characterized by morphological and metabolic changes, chromatin remodeling, changes in gene_expression, and the appearance of a proinflammatory phenotype known as the senescence-associated secretory phenotype (SASP). molecular mechanism by which SWT affects breast cancer from the perspective of cellular senescence induction. In recent years, many studies have shown that TCM induces cell senescence by inhibiting telomerase activity, inducing DNA damage, inducing SASP development . . .
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