Elucidation of the substrate of trna-modifying enzymes mnmeg leads to in vitro reconstitution of an evolutionarily conserved uridine hypermodification

HIGHLIGHTS

• who: Praneeth Bommisetti from the Praneeth Bommisetti1, Anthony Young2, and Vahe Bandarian1, * From the Department of Chemistry, University of Utah, Salt Lake City, Utah, USA have published the research: Elucidation of the substrate of tRNA-modifying enzymes MnmEG leads to inu00a0vitro reconstitution of an evolutionarily conserved uridine hypermodification, in the Journal: (JOURNAL) of August/25,/2022
• what: Using isotopically labeled methyl and methylene THF analogs, the authors demonstrate that methylene THF is the true substrate. The authors report in_vitro biochemical reconstitution of the MnmEG reaction using well-defined isotopically enriched substrates. The authors show that . . .
  

   

  

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